United States regulatory requirements for skin and eye irritation testing

Nasal, eye, and skin irritation in dockyard painters.

OBJECTIVES To determine whether the risk of irritant symptoms in painters is related to their exposure to paint. METHODS The prevalences of skin, eye and nasal symptoms were compared in 260 United Kingdom and 109 Chinese dockyard painters, 539 British community controls, and 255 Chinese dockyard controls, relative to their exposure to paints. RESULTS Painters showed an excess of irritant sy...

Alternative methods for the replacement of eye irritation testing.

In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test has been criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize substances according to the global harmonized system...

Alternative methods for skin irritation testing: the current status.

The potential for chemicals to cause skin corrosion or skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals. The determination of skin corrosion and irritation potential is therefore included in international regulatory requirements for the testing of chemicals. The standard approach used involves applying the test ma...

Skin irritation and corrosion.

Application of Alternative Methods in the Regulatory Assessment of Chemical Safety Related to Human Eye Irritation & Severe Eye Irritation